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TJM receiving a certificate of donation from the curator at the Provincial museum  (Museo Provincial Mayor General Vicente Garcia Gonzalez)  in Las Tunas, Cuba (summer, 2001).  The 55 year old pictures of United States Marines, stationed in Guantanemo Bay, in Las Tunas (Jim Manning Sr. included) will hang at the 250th Anniversary of the museum in eastern Cuba!  (TRIP SUMMARY)



Educational background

Research Interests (Active in four areas):

1. Nanotechnology.  Organized nanotechnology symposium at South East Regional Meeting of the American Chemical Society, held in Savannah, fall 2001 (SERMACS, click here for program). Our Research Group has done work in the following areas:

      a. Production of Nanostructures from Graphite Intercalated Compounds.

Figure 1 (above). Carbon nanotubes that are 2-4 nanometers wide produced by impulse heating a graphite intercalated compound in a 27.12 MHz Inductively Coupled Plasma. (HRTEM) The nanotubes are the thin somewhat transparent lines (TEM and SEM's courtesy of Kim Riddle, FSU Bio department EM lab).

Figure 2 (above). Exfoliated graphite (EG) produced when fluorinated graphite dust is impulse heated from room temperature to 7,500 degrees in less than 1 ms. The material (EG) is completely defluorinated and stable at room temperature  (SEM, 10,000 X mag). 

      b. Electrochemical production of polymer nanospheres.

Figure 3 (above). Nanospheres (10-12 nm diameter) of fluorinated graphite produced by a low temperature electrochemical approach developed in this lab. (HRTEM, 500,000 X  mag)

      c. Production of Spherical Allotropes of Carbon Via a High Voltage, High Frequency     Electrical Discharge.

Figure 4.  Mass Spec peaks in the 720-750 amu and 840-870 amu range are hydrogenated fullerenes (HxC60 and HyC70).  Peaks in lower range (400-600 amu) are various polyaromatic hydrocarbons (PAH's) that are precursors.  Below is mass spec of what may be C48N12  (and protonated).  We've been able to make grams of the compounds! (MS courtesy of Dennis Phillips, UGa Mass Spec lab)

sample pubs:

T. Manning, A. Noel*, M. Mitchell*, A. Miller*, W. Grow*, G. Gaddy*, K. Riddle, K. Taylor, J. Stach. Impulse Heating an Intercalated Compound using a 27.12 MHz Atmospheric Inductively Coupled Argon Plasma to Produce Nanotubular Structure.  Book Chapter in Science and Application of Nanotubes, Fundamental Materials Research Series, Edited by D. Tomanek, Plenum Publishers (2000)

T. Manning, M. Mitchell*, J. Stach, T. Vickers, “Synthesis of exfoliated graphite from fluorinated graphite using an atmospheric-pressure argon plasma" Carbon 37, p. 1159 (1999)

Thomas J. Manning*, Amy Feldman, Michael Anderson, Leri Atwater, Brent Lesile, Derek Lovingood, Anna Lee McRae, Rob Stapleton, Synthesis of Nanospheres of Fluorinated Graphite Using an Electrochemical Approach, Journal of Nanoparticle Research (submitted, 12/2001)

T.  Manning, T. Ellison, High Voltage, High frequency Production of Fullerenes, Fullerene Nanotubes and Carbon Nanostructures (manuscript in prep, 2002)

2. Ozone Generation and Application.  Our research group has done pioneering work in the area of mixed gas ozone generation and developing a low cost, rugged system (US Patent 6,022,456).  Currently we have a funded project using ozone to remove/eliminate viral infections in shrimp aquaculture.  (Ozone Background and History of Patent Pages: click here)

Figure 5. Ozone has been shown to eliminate viral infections that can wipe out shrimp farms.  TJM is PI on a project, located at the NESPAL lab in Tifton (GA), to develop an innovative ozone process to make freshwater shrimp farming a reality.   

sample pubs:

T. Manning, Production of Ozone in an Electrical Discharge Using Inert Gases as Catalysts , p. 53-65, Ozone: Sci. Eng., vol. 22, #1 (2000)

T. Manning, J. Hedden*, “Gas Mixtures and Ozone Production in an Electrical Discharge”  Ozone Sci. Eng. Vol. 23, pp.95-103 (2001)

T. J. Manning, “Inert Gases as catalyst for Ozone Generation,”  US Patent #6,022,456 (assigned to VSU), Feb. 8th, 2000

3. Natural Products Discovery.  Our original work with humic substances has been modified to search or scan an ecosystem for molecules of medicinal value.  We recently filed a patent application related to work with bryostatin, a large organic molecule with strong anti-cancer properties.          

Figure 6. (above) Matrix assisted Laser Desorption Ionization (MALDI)- Mass Spectrometer spectra of nonpolar extract shows peak at 887 amu, the same MW as bryostatin - the strong anti-cancer drug!  Did we find the origin of this natural product - not from bryozoa??

Figure 7. (above) Bryostatin 1, an experimental anticancer drug, sold by LC Labs, has a molecular weight of 887 amu's. 

sample pubs:

T. Manning, T. Umberger, S. Strickland, T. Bennett*, M. Sherrill*, D. Lovingood, L. Noble, D. Phillips,  J. Manning,  Humic Substances as a Chemical cage to Scan an Ecosystem for Natural Product Identification” submitted (11/2001), Env. Sci. Tech.

T. Manning, T. Bennett*, D. Milton*,  Multiangle Laser Light Scattering to determine the Size and Molecular Weight of Humic Acid. Science Total Environment, 257, p. 171-176 (2000)

T. Manning, “Extraction of Natural Products from Humic Substances.”  Patent Applied for via VSU (filed Feb, 2001)

4. Educational Projects:  Students in upper level classes routinely participate in exploratory projects that are taught at the "peer review level" (good enough to publish).  These projects have ranged from basic atomic physics to intellectual property to molecular evolution. 

Figure 8. (above) Students in Instrumental Analysis (spring, 2001). Leri Atwater (left) and Anna Leigh McRae co-authored a paper related to intellectual property development in an undergraduate chemistry curriculum. 

sample pubs:

A. Feldman*, L. Atwater*, B. Leslie*, R. Stapleton*, D. Lovingood*, M. Anderson*, A. McRae*, T. Manning, N. Dalal, T. Vickers, K. Riddle, Exploratory lab in Nanotechnology,  published, 1/2001), The Chemical Educator

T. Manning, Leri Atwater, Derek Lovingood, Tice Umberger, Anna Lee McRae, Mike Anderson, T. Ellison, Brent Leslie, Mary Watson,  “Introduction of Intellectual Property into a Chemistry Curriculum.” (published, The Chemical Educator) summer 2001

W.R.Grow* and T. Manning, "Calculating Nuclear Spin from Hyperfine Structure" The Chemical Educator (published,  November, 1997)

We also do projects in other areas ranging from MRI Contrast Reagents to Fundamental Structural Studies of Bioactive Peptides to Thermodynamic Models of Metal-Ligand Interactions.

sample pubs:

T. Manning, W. Fiskus*, M. Mitchell*, Leigh Ann Dees* "Protonation Constants of Gd(III)-DTPA by ICP-AES"   Spectroscopy Letters (1998)  

T.J. Manning, "Resolution and Signal to Noise Ratios in Fourier Transform Spectroscopy" 29(11) p. 2001 (1996)   Analytical Letters

 T.J. Manning, "A Wavenumber, Intensity, and Resolution Standard for High Resolution Ultraviolet/Visible Fourier transform Spectroscopy"  29(5) p. 959  Spectroscopy Letters    (1996)

 T. Manning, P. Tonui*, A. Miller*, S. Topurek, D. Powell, "Proton Magnetic Resonance Studies of Methionine Enkephalin"  Biochemical and Biophysical Research Communications 226, 796-800 (1996)

T. J. Manning, "Approximating the Electrostatic Contribution to DS for Aqueous Phase Lanthanide-Aminocarboxylate Complexation"  p. 661, vol. 73, #7 (1996)  Journal of Chemical Education




Last year I traveled to Cuba (Click to see trip outline), with a group of faculty from University System of Georgia institutions, to pursue collaborations with academic and economic overtures.  In addition the trip had a brief encounter of personal importance (click for trip final report).    

Pictures from the past - Teaching Honors Class:

Figure 9 a,b (above, below).  During an Environmental Science class trip to the Florida Keys in 1997, the guys on the trip were corralled into some manual labor at Pigeon Key Research Center , while the girls got to look for flipper!  Some of the guys pictured were also research students with TJM - Including Greg Gaddy (PhD Auburn University 2001, currently NASA Scientist), Peter Tonui (Northwestern Medical School, Class of 2002), Walter Lawhorn (Mercer Doctor of Pharmacy, Class of 2002) and Mike Mitchell (Georgia Tech, EE). The late Chris Cowart (passed away while a second year med school student at Mercer) was also in the class - we have fond memories of Chris - a good friend and a great guy!  Mike's wife (Michelle) was also in the class.  Dr. Drew Hyatt (Geosciences) and Dr. Linda Chamberlin (biology) were also on the trip! 

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